Scientific publications

July 2023
A sensitive and rapid LC-MS/MS assay for quantitation of free payload Aur0101 from antibody drug conjugate (ADC) PYX-201 in human plasma (J Chromatogr B Analyt Technol Biomed Life Sci. 2023 Jul 15:1226:123786.)
Article
July 2023
A sensitive LC–MS/MS assay to quantitate free payload Aur0101 from ADC PYX-201 in rat and monkey plasma (Bioanalysis. 2023 Jul;15(14):833-843.)
Article
June 2023
A Phase 2 Trial with a Safety Lead-in to Evaluate the Addition of Sotigalimab, a CD40 Agonistic Monoclonal Antibody, to Standard-of-Care Doxorubicin for the Treatment of Advanced Sarcoma
ASCO Poster
May 2023
Bioanalysis of an antibody drug conjugate (ADC) PYX-201 in human plasma using a hybrid immunoaffinity LC–MS/MS approach (J Chromatogr B Analyt Technol Biomed Life Sci. 2023 May 15:1223:123715.)
Article
January 2023
Tissue Assessment of Therapeutic Responses to Neoadjuvant SCRT with and without Anit-CD40 Immunotherapy Sotigalimab (Sotiga) in Rectal Cancer
ASCO GI Poster
January 2023
Use of High-dimensional and Spatial Immune Profiling to Explore Sotigalimab (CD40 Agonist) Activation of Antigen Presenting Cells and T Cells in the Tumor Microenvironment in Patients with Esophageal/Gastroesophageal Junction Cancer
ASCO GI Poster
January 2023
Quantification of antibody–drug conjugate PYX-201 in rat and monkey plasma via ELISA and its application in preclinical studies (Bioanalysis. 2023 Jan;15(1):43-52.)
Article
November 2022
Intratumoral Sotigalimab with Pembrolizumab Activates Antigen Presenting cells and Induces Local and Distant Anti Tumor Responses in First line Metastatic Melanoma: Results of a Phase I/II Study
SITC Presentation
September 2022
A Multicenter Phase 2 Study of Sotigalimab (CD40 Agonist) in Combination with Neoadjuvant Chemoradiation for Resectable Esophageal and Gastroesophageal Junction (GEJ) Cancers
ESMO Poster
June 2022
Distinct Biosignatures Associate with Survival After Chemoimmunotherapy in a Randomized, Three-arm Phase II Study in Patients with Metastatic Pancreatic Cancer
ASCO Presentation