Scientific publications

April 2024
PYX-106, Gene expression correlation of immune checkpoint molecules Siglec-15 and PD-L1 varies widely by cancer indication – Abstract Number: 1373
AACR Poster
April 2024
Safety and Tolerability of a Novel Anti-HER2 Antibody–Drug Conjugate (PF-06804103) in Patients with HER2-Expressing Solid Tumors: A Phase 1 Dose-Escalation Study (Mol Cancer Ther. 2023 Oct 2;22(10):1191-1203.)
Article
April 2024
Anti-Extra Domain B Splice Variant of Fibronectin Antibody–Drug Conjugate Eliminates Tumors with Enhanced Efficacy When Combined with Checkpoint Blockade (Mol Cancer Ther. 2022 Sep 6;21(9):1462-1472.)
Article
April 2024
PF-06804103, A Site-specific Anti-HER2 Antibody–Drug Conjugate for the Treatment of HER2-expressing Breast, Gastric, and Lung Cancers (Mol Cancer Ther. 2020 Oct;19(10):2068-2078.)
Article
November 2023
CD40 Agonism Remodels the Tumor Immune Microenvironment in Locally Advanced Esophageal/Gastroesophageal Junction Cancer – Poster Number: 1361
SITC Poster
November 2023
PYX-102, an Anti-KLRG1 Antibody, Enhances Cytotoxic Activity of CD8 T cells from PBMC and Human Tumor Samples by Blocking the Interaction Between KLRG1 and Cadherins Poster Number: 572
SITC Poster
November 2023
First-in-Human, Open-label, Multicenter, Phase 1 Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of anti Siglec-15 PYX-106 in Subjects with Advanced Solid Tumors Poster Number: 756
SITC Poster
November 2023
A First-in-Human Phase 1 Clinical Study Evaluating Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of the EDB+FN targeting ADC PYX-201 in Participants with Advanced Solid Tumors Poster Number: 762
SITC Poster
September 2023
Quantitation of total antibody (tAb) from antibody drug conjugate (ADC) PYX-201 in rat and monkey plasma using an enzyme-linked immunosorbent assay (ELISA) and its application in preclinical studies (J Pharm Biomed Anal 2023 Sep 5:233:115452.)
Article
August 2023
Development and validation of a hybrid immunoaffinity LC–MS/MS assay for quantitation of total antibody (TAb) from an antibody drug conjugate (ADC) PYX-201 in human plasma (J Chromatogr B Analyt Technol Biomed Life Sci. 2023 Aug 1:1228:123844.)
Article