Scientific publications

April 2024
PYX-201, EDB+FN is an attractive target in oncology: Insights from protein expression analysis of solid tumors – Abstract Number: 2908
AACR Poster
April 2024
PYX-201, a stroma-targeting ADC composed of an anti-EDB+FN antibody conjugated to Auristatin0101, demonstrates strong anti-tumor efficacy across multiple human cancer indications in pre-clinical PDX tumor models – Abstract Number: 742
AACR Poster
April 2024
Extracellular proteolytic cleavage of peptide-linked antibody-drug conjugates promotes bystander killing of cancer cells – Abstract Number: 4837
AACR 2014 Pfizer Poster
April 2024
PYX-106, Gene expression correlation of immune checkpoint molecules Siglec-15 and PD-L1 varies widely by cancer indication – Abstract Number: 1373
AACR Poster
April 2024
Safety and Tolerability of a Novel Anti-HER2 Antibody–Drug Conjugate (PF-06804103) in Patients with HER2-Expressing Solid Tumors: A Phase 1 Dose-Escalation Study (Mol Cancer Ther. 2023 Oct 2;22(10):1191-1203.)
Article
April 2024
Anti-Extra Domain B Splice Variant of Fibronectin Antibody–Drug Conjugate Eliminates Tumors with Enhanced Efficacy When Combined with Checkpoint Blockade (Mol Cancer Ther. 2022 Sep 6;21(9):1462-1472.)
Article
April 2024
PF-06804103, A Site-specific Anti-HER2 Antibody–Drug Conjugate for the Treatment of HER2-expressing Breast, Gastric, and Lung Cancers (Mol Cancer Ther. 2020 Oct;19(10):2068-2078.)
Article
November 2023
CD40 Agonism Remodels the Tumor Immune Microenvironment in Locally Advanced Esophageal/Gastroesophageal Junction Cancer – Poster Number: 1361
SITC Poster
November 2023
PYX-102, an Anti-KLRG1 Antibody, Enhances Cytotoxic Activity of CD8 T cells from PBMC and Human Tumor Samples by Blocking the Interaction Between KLRG1 and Cadherins Poster Number: 572
SITC Poster
November 2023
First-in-Human, Open-label, Multicenter, Phase 1 Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of anti Siglec-15 PYX-106 in Subjects with Advanced Solid Tumors Poster Number: 756
SITC Poster
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