Pyxis Oncology is seeking a passionate, creative, deeply skilled immunologist to join our Discovery Research team. The successful candidate will develop and execute in vitro and ex vivo cell-based immunoassays to understand the mechanisms underlying activity of novel cancer immunotherapy targets while helping drive forward our therapeutic antibody programs with which we hope to defeat difficult to treat cancers. The ideal candidate will be curious, resourceful, and proactive in turning biological findings into results that help move our potential therapies toward the clinic. The candidate should enjoy collaborating as a team player in a fast-paced, exciting, ever-changing startup environment.
- Develop and execute protein, cell, and tissue-based mechanistic T cell and NK cell focused in vitro assays to support advancement of novel immunotherapies from research through to development stage.
- Identify and design suitable in vitro or in vivo assays to answer questions surrounding target biology, therapeutic development, and translational/biomarker strategy.
- Thoroughly document experiments and clearly communicate results across functional teams in internal- and external-facing environments.
- Interact with other team members in a matrix environment, with collaborators in industry and academia, as well as with CROs across the globe.
- Ph.D. in Immunology or a related field with at least 3+ years of relevant laboratory experience, or BS/MS with 10+ years of relevant laboratory experience, including academic or industrial experience.
- Comfort in leading the development and execution of T cell and NK cell functional cell-based assays including cell activation, proliferation, Treg suppression, MLR, CTL activity, ADCC, and CDC assays.
- Proficiency in independently designing and executing experiments, analyzing data, and reporting conclusions.
- Transparent in communication, documentation, and data sharing with an understanding that scientific excellence is driven by integrity.
- Expertise in cellular and protein immunology including multi-color flow cytometry (FACS analysis and cell sorting) and cytokine profiling (ELISA, MSD, Luminex).
- Hands-on experience with mammalian cell culture, lentiviral transduction, tissue dissociation, immunophenotyping, and reporter bioassay development.
- An understanding of antibody therapeutic discovery and preclinical development is desired.
- Experience with in vivo tumor models is helpful.
- Excellent organizational and time management skills.
- Ability to thrive in a highly collaborative, fast-paced, team-oriented environment with colleagues from diverse disciplines.
- Ability to work with human and animal tissue and blood or blood products.
- Must be eligible to work in the United States without sponsorship.
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